Batova M~Schuller C, 2010

Pubmed ID 20202201
Title Chemogenomic and transcriptome analysis identifies mode of action of the chemosensitizing agent CTBT (7-chlorotetrazolo[5,1-c]benzo[1,2,4]triazine).
Authors Monika Batova, Vlasta Klobucnikova, Zuzana Oblasova, Juraj Gregan, Pavol Zahradnik, Ivan Hapala, Julius Subik, Christoph Schüller
Abstract CTBT (7-chlorotetrazolo [5,1-c]benzo[1,2,4]triazine) increases efficacy of commonly used antifungal agents by an unknown mechanism. It increases the susceptibility of Saccharomyces cerevisiae, Candida albicans and Candida glabrata cells to cycloheximide, 5-fluorocytosine and azole antimycotic drugs. Here we elucidate CTBT mode of action with a combination of systematic genetic and transcriptome analysis.
Citation BMC Genomics 2010; 11:153

Datasets

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Paper Phenotype Condition Medium Collection Tested mutants Data Details
Batova M~Schuller C, 2010 growth (colony size) CTBT [2 ug/ml] hap a ~4,700 Discrete
Batova M~Schuller C, 2010 growth (colony size) CTBT [4 ug/ml] hap a ~4,700 Discrete

Curation history

Data

March 26, 2014 Waiting for tested.
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Oct. 7, 2016 Loaded.

Tested strains

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