||Identification of gold nanoparticle-resistant mutants of Saccharomyces cerevisiae suggests a role for respiratory metabolism in mediating toxicity.
||Mark R Smith, Matthew G Boenzli, Vihangi Hindagolla, Jun Ding, John M Miller, James E Hutchison, Jeffrey A Greenwood, Hagai Abeliovich, Alan T Bakalinsky
||Positively charged gold nanoparticles (0.8-nm core diameter) reduced yeast survival, but not growth, at a concentration of 10 to 100 μg/ml. Among 17 resistant deletion mutants isolated in a genome-wide screen, highly significant enrichment was observed for respiration-deficient mutants lacking genes encoding proteins associated with the mitochondrion.
||Appl. Environ. Microbiol. 2013; 79:728-33
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