Smith MR~Bakalinsky AT, 2013

Pubmed ID 23144132
Title Identification of gold nanoparticle-resistant mutants of Saccharomyces cerevisiae suggests a role for respiratory metabolism in mediating toxicity.
Authors Mark R Smith, Matthew G Boenzli, Vihangi Hindagolla, Jun Ding, John M Miller, James E Hutchison, Jeffrey A Greenwood, Hagai Abeliovich, Alan T Bakalinsky
Abstract Positively charged gold nanoparticles (0.8-nm core diameter) reduced yeast survival, but not growth, at a concentration of 10 to 100 μg/ml. Among 17 resistant deletion mutants isolated in a genome-wide screen, highly significant enrichment was observed for respiration-deficient mutants lacking genes encoding proteins associated with the mitochondrion.
Citation Appl. Environ. Microbiol. 2013; 79:728-33


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Papers Phenotype Conditions Collection Tested mutants Data Details
Smith MR~Bakalinsky AT, 2013 growth (CFU) gold nanoparticles [10-100 ug/ml] hap alpha 4,773 Quantitative only for hits

Curation history

March 17, 2014 Tested strains to request.
March 17, 2014 Data to request.
April 3, 2014 Tested strains to load.
April 3, 2014 Data to load.
April 7, 2014 Tested strains loaded.
April 7, 2014 Data loaded.