Bennett CB~Resnick MA, 2001

Pubmed ID 11726929
Title Genes required for ionizing radiation resistance in yeast.
Authors C B Bennett, L K Lewis, G Karthikeyan, K S Lobachev, Y H Jin, J F Sterling, J R Snipe, M A Resnick
Abstract The ability of Saccharomyces cerevisiae to tolerate ionizing radiation damage requires many DNA-repair and checkpoint genes, most having human orthologs. A genome-wide screen of diploid mutants homozygous with respect to deletions of 3,670 nonessential genes revealed 107 new loci that influence gamma-ray sensitivity. Many affect replication, recombination and checkpoint functions. Nearly 90% were sensitive to other agents, and most new genes could be assigned to the following functional groups: chromatin remodeling, chromosome segregation, nuclear pore formation, transcription, Golgi/vacuolar activities, ubiquitin-mediated protein degradation, cytokinesis, mitochondrial activity and cell wall maintenance. Over 50% share homology with human genes, including 17 implicated in cancer, indicating that a large set of newly identified human genes may have related roles in the toleration of radiation damage.
Citation Nat. Genet. 2001; 29:426-34

Datasets

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Paper Phenotype Condition Medium Collection Tested mutants Data Details
Bennett CB~Resnick MA, 2001 growth (colony size) gamma-irradiation [80 Krads] YPD hom ~3,670 Discrete

Curation history

Data

March 28, 2016 Waiting for tested.
July 6, 2016 Ready to load.
Sept. 6, 2016 Loaded.

Tested strains

April 12, 2016 To request.
April 25, 2016 Request sent.
June 10, 2016 Request sent.
July 6, 2016 Not available.