Bennett CB~Resnick MA, 2001

Pubmed ID 11726929
Title Genes required for ionizing radiation resistance in yeast.
Authors C B Bennett, L K Lewis, G Karthikeyan, K S Lobachev, Y H Jin, J F Sterling, J R Snipe, M A Resnick
Abstract The ability of Saccharomyces cerevisiae to tolerate ionizing radiation damage requires many DNA-repair and checkpoint genes, most having human orthologs. A genome-wide screen of diploid mutants homozygous with respect to deletions of 3,670 nonessential genes revealed 107 new loci that influence gamma-ray sensitivity. Many affect replication, recombination and checkpoint functions. Nearly 90% were sensitive to other agents, and most new genes could be assigned to the following functional groups: chromatin remodeling, chromosome segregation, nuclear pore formation, transcription, Golgi/vacuolar activities, ubiquitin-mediated protein degradation, cytokinesis, mitochondrial activity and cell wall maintenance. Over 50% share homology with human genes, including 17 implicated in cancer, indicating that a large set of newly identified human genes may have related roles in the toleration of radiation damage.
Citation Nat. Genet. 2001; 29:426-34


Download the list of datasets
Paper Phenotype Condition Medium Collection Tested mutants Data Details
Bennett CB~Resnick MA, 2001 growth (colony size) gamma-irradiation [80 Krads] YPD hom ~3,670 Discrete

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March 28, 2016 Waiting for tested.
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