||Integrating phenotypic and expression profiles to map arsenic-response networks.
||Astrid C Haugen, Ryan Kelley, Jennifer B Collins, Charles J Tucker, Changchun Deng, Cynthia A Afshari, J Martin Brown, Trey Ideker, Bennett Van Houten
||Arsenic is a nonmutagenic carcinogen affecting millions of people. The cellular impact of this metalloid in Saccharomyces cerevisiae was determined by profiling global gene expression and sensitivity phenotypes. These data were then mapped to a metabolic network composed of all known biochemical reactions in yeast, as well as the yeast network of 20,985 protein-protein/protein-DNA interactions.
||Genome Biol. 2004; 5:R95
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