Marston AL~Amon A, 2004

Pubmed ID 14752166
Title A genome-wide screen identifies genes required for centromeric cohesion.
Authors Adele L Marston, Wai-Hong Tham, Hiral Shah, Angelika Amon
Abstract During meiosis, two chromosome segregation phases follow a single round of DNA replication. We identified factors required to establish this specialized cell cycle by examining meiotic chromosome segregation in a collection of yeast strains lacking all nonessential genes. This analysis revealed Sgo1, Chl4, and Iml3 to be important for retaining centromeric cohesin until the onset of anaphase II. Consistent with this role, Sgo1 localizes to centromeric regions but dissociates at the onset of anaphase II. The screen described here provides a comprehensive analysis of the genes required for the meiotic cell cycle and identifies three factors important for the stepwise loss of sister chromatid cohesion.
Citation Science 2004; 303:1367-70

Datasets

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Paper Phenotype Condition Reference Collection Tested mutants Data Details
Marston AL~Amon A, 2004 sporulation efficiency sporulation medium [unknown] hom 4,677 Quantitative
Marston AL~Amon A, 2004 chromosome segregation (percentage of tetrads with 1 chromosome/cell) sporulation medium [unknown] hom 4,522 Quantitative
Marston AL~Amon A, 2004 dyad formation (percentage of cells forming dyads) sporulation medium [unknown] hom 4,674 Quantitative

Curation history

Tested strains

Sept. 19, 2016 Ready to load.
Sept. 22, 2016 Loaded.

Data

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Sept. 22, 2016 Loaded.