Dilda PJ~Hogg PJ, 2005

Pubmed ID 16234568
Title Mechanism of selectivity of an angiogenesis inhibitor from screening a genome-wide set of Saccharomyces cerevisiae deletion strains.
Authors Pierre J Dilda, Anthony S Don, Kara M Tanabe, Vincent J Higgins, John D Allen, Ian W Dawes, Philip J Hogg
Abstract The synthetic tripeptide arsenical 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) is an angiogenesis inhibitor that targets the mitochondria of actively dividing but not quiescent endothelial cells, arresting their proliferation and causing apoptosis. Normal endothelial cells are much more sensitive to GSAO than tumor cells. To elucidate the mechanism of tumor cell resistance, we identified yeast genes that are necessary for resistance to GSAO.
Citation J. Natl. Cancer Inst. 2005; 97:1539-47

Datasets

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Papers Phenotype Conditions Collection Tested mutants Data Details
Dilda PJ~Hogg PJ, 2005 growth (culture turbidity) S-{2-[4-(dihydroxyarsino)phenylamino]-2-oxoethyl}-glutathione [0.5-2 mM] hom ~4,546 Discrete

Curation history

Sept. 26, 2016 Tested strains to request.
Sept. 26, 2016 Tested strains requested.
Sept. 26, 2016 Tested strains abandoned.
Sept. 26, 2016 Data to request.
Sept. 26, 2016 Data requested.
Sept. 26, 2016 Data abandoned.
Sept. 26, 2016 Data to load.
Oct. 14, 2016 Data loaded.