Dilda PJ~Hogg PJ, 2005

Pubmed ID 16234568
Title Mechanism of selectivity of an angiogenesis inhibitor from screening a genome-wide set of Saccharomyces cerevisiae deletion strains.
Authors Pierre J Dilda, Anthony S Don, Kara M Tanabe, Vincent J Higgins, John D Allen, Ian W Dawes, Philip J Hogg
Abstract The synthetic tripeptide arsenical 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) is an angiogenesis inhibitor that targets the mitochondria of actively dividing but not quiescent endothelial cells, arresting their proliferation and causing apoptosis. Normal endothelial cells are much more sensitive to GSAO than tumor cells. To elucidate the mechanism of tumor cell resistance, we identified yeast genes that are necessary for resistance to GSAO.
Citation J. Natl. Cancer Inst. 2005; 97:1539-47

Datasets

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Paper Phenotype Condition Medium Collection Tested mutants Data Details
Dilda PJ~Hogg PJ, 2005 growth (culture turbidity) S-{2-[4-(dihydroxyarsino)phenylamino]-2-oxoethyl}-glutathione [0.5-2 mM] YPD hom ~4,546 Discrete

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