Fujita K~Iwahashi H, 2006

Pubmed ID 16879425
Title The genome-wide screening of yeast deletion mutants to identify the genes required for tolerance to ethanol and other alcohols.
Authors Katsuhide Fujita, Akinobu Matsuyama, Yoshinori Kobayashi, Hitoshi Iwahashi
Abstract A set of homozygous diploid deletion mutants of the yeast Saccharomyces cerevisiae was screened for the genes required for tolerance to aliphatic alcohols. The screen identified 137, 122 and 48 deletion mutants sensitive to ethanol, 1-propanol and 1-pentanol, respectively. A number of the genes required for ethanol tolerance were those also required for tolerance to other alcohols. Numerous mutants with defective genes encoding for vacuolar H+ -ATPase (V-ATPase) were cosensitive to these alcohols. A global screening approach of yeast deletion library mutants was useful in elucidating the mechanisms of alcohol tolerance based on different lipophilicities.
Citation FEMS Yeast Res. 2006; 6:744-50

Datasets

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Paper Phenotype Condition Medium Collection Tested mutants Data Details
Fujita K~Iwahashi H, 2006 growth (spot assay) ethanol [10%] hom ~4,500 Discrete
Fujita K~Iwahashi H, 2006 growth (spot assay) propan-1-ol [4%] hom ~4,500 Discrete
Fujita K~Iwahashi H, 2006 growth (spot assay) pentan-1-ol [0.5%] hom ~4,500 Discrete

Curation history

Data

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April 18, 2017 Loaded.

Tested strains

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Nov. 2, 2016 Not available.