Snoek IS~Steensma HY, 2006

Pubmed ID 16630279
Title Why does Kluyveromyces lactis not grow under anaerobic conditions? Comparison of essential anaerobic genes of Saccharomyces cerevisiae with the Kluyveromyces lactis genome.
Authors I S Ishtar Snoek, H Yde Steensma
Abstract Although some yeast species, e.g. Saccharomyces cerevisiae, can grow under anaerobic conditions, Kluyveromyces lactis cannot. In a systematic study, we have determined which S. cerevisiae genes are required for growth without oxygen. This has been done by using the yeast deletion library. Both aerobically essential and nonessential genes have been tested for their necessity for anaerobic growth. Upon comparison of the K. lactis genome with the genes found to be anaerobically important in S. cerevisiae, which yielded 20 genes that are missing in K. lactis, we hypothesize that lack of import of sterols might be one of the more important reasons that K. lactis cannot grow in the absence of oxygen.
Citation FEMS Yeast Res 2006; 6:393-403
Data abstract Deletion collection was assayed for growth under anaerobic conditions.
Notes This study also includes a list of essential genes that are not required for growth in anaerobic conditions.


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Paper Phenotype Condition Medium Collection Tested mutants Data Details
Snoek IS~Steensma HY, 2006 growth (culture turbidity) oxygen [0%] YPDET + G418 hom 4,717 Discrete

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