Narayanaswamy R~Marcotte EM, 2006

Pubmed ID 16507139
Title Systematic profiling of cellular phenotypes with spotted cell microarrays reveals mating-pheromone response genes.
Authors Rammohan Narayanaswamy, Wei Niu, Alexander D Scouras, G Traver Hart, Jonathan Davies, Andrew D Ellington, Vishwanath R Iyer, Edward M Marcotte
Abstract We have developed spotted cell microarrays for measuring cellular phenotypes on a large scale. Collections of cells are printed, stained for subcellular features, then imaged via automated, high-throughput microscopy, allowing systematic phenotypic characterization. We used this technology to identify genes involved in the response of yeast to mating pheromone. Besides morphology assays, cell microarrays should be valuable for high-throughput in situ hybridization and immunoassays, enabling new classes of genetic assays based on cell imaging.
Citation Genome Biol. 2006; 7:R6

Datasets

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Paper Phenotype Condition Medium Collection Tested mutants Data Details
Narayanaswamy R~Marcotte EM, 2006 slight shmoo standard YPD hap a 4,766 Discrete
Narayanaswamy R~Marcotte EM, 2006 cell size standard YPD hap a 4,579 Discrete
Narayanaswamy R~Marcotte EM, 2006 round cell shape standard YPD hap a 4,579 Discrete
Narayanaswamy R~Marcotte EM, 2006 pointed cell shape standard YPD hap a 4,579 Discrete
Narayanaswamy R~Marcotte EM, 2006 elongated cell shape standard YPD hap a 4,579 Discrete
Narayanaswamy R~Marcotte EM, 2006 pseudohyphal-like cell shape standard YPD hap a 4,579 Discrete
Narayanaswamy R~Marcotte EM, 2006 clumped cell shape standard YPD hap a 4,579 Discrete
Narayanaswamy R~Marcotte EM, 2006 budding cell shape standard YPD hap a 4,579 Discrete
Narayanaswamy R~Marcotte EM, 2006 polarized bud growth cell shape standard YPD hap a 4,579 Discrete

Curation history

Data

June 10, 2014 Ready to load.
Jan. 28, 2015 Loaded.

Tested strains

June 10, 2014 Ready to load.
Jan. 28, 2015 Loaded.