| Pubmed ID | 24968945 |
|---|---|
| Title | High throughput screening identifies modulators of histone deacetylase inhibitors. |
| Authors | Ann-Christin Gaupel, Thomas Begley, Martin Tenniswood |
| Abstract | Previous studies from our laboratory and others have demonstrated that in addition to altering chromatin acetylation and conformation, histone deacetylase inhibitors (HDACi) disrupt the acetylation status of numerous transcription factors and other proteins. A whole genome yeast deletion library screen was used to identify components of the transcriptional apparatus that modulate the sensitivity to the hydroxamic acid-based HDACi, CG-1521. |
| Citation | BMC Genomics 2014; 15:528 |
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