Vásquez-Soto B~Norambuena L, 2015

Pubmed ID 26209329
Title Sortin2 enhances endocytic trafficking towards the vacuole in Saccharomyces cerevisiae.
Authors Beatriz Vásquez-Soto, Nicolás Manríquez, Mirna Cruz-Amaya, Jan Zouhar, Natasha V Raikhel, Lorena Norambuena
Abstract A highly regulated trafficking of cargo vesicles in eukaryotes performs protein delivery to a variety of cellular compartments of endomembrane system. The two main routes, the secretory and the endocytic pathways have pivotal functions in uni- and multi-cellular organisms. Protein delivery and targeting includes cargo recognition, vesicle formation and fusion. Developing new tools to modulate protein trafficking allows better understanding the endomembrane system mechanisms and their regulation. The compound Sortin2 has been described as a protein trafficking modulator affecting targeting of the vacuolar protein carboxypeptidase Y (CPY), triggering its secretion in Saccharomyces cerevisiae.
Citation Biol. Res. 2015; 48:39

Datasets

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Paper Phenotype Condition Medium Collection Tested mutants Data Details
Vásquez-Soto B~Norambuena L, 2015 transport to/from cell surface (CPY) dimethyl sulfoxide [1%], Sortin2 [47 uM] YPD hap alpha 4,773 Discrete

Curation history

Data

April 21, 2016 Waiting for tested.
May 19, 2016 Ready to load.
June 10, 2016 Loaded.

Tested strains

April 21, 2016 To request.
April 25, 2016 Request sent.
May 19, 2016 Ready to load.
June 10, 2016 Loaded.