Sousa M~Sousa MJ, 2013

Pubmed ID 24286259
Title Genome-wide identification of genes involved in the positive and negative regulation of acetic acid-induced programmed cell death in Saccharomyces cerevisiae.
Authors Marlene Sousa, Ana Marta Duarte, Tânia R Fernandes, Susana R Chaves, Andreia Pacheco, Cecília Leão, Manuela Côrte-Real, Maria João Sousa
Abstract Acetic acid is mostly known as a toxic by-product of alcoholic fermentation carried out by Saccharomyces cerevisiae, which it frequently impairs. The more recent finding that acetic acid triggers apoptotic programmed cell death (PCD) in yeast sparked an interest to develop strategies to modulate this process, to improve several biotechnological applications, but also for biomedical research. Indeed, acetate can trigger apoptosis in cancer cells, suggesting its exploitation as an anticancer compound. Therefore, we aimed to identify genes involved in the positive and negative regulation of acetic acid-induced PCD by optimizing a functional analysis of a yeast Euroscarf knock-out mutant collection.
Citation BMC Genomics 2013; 14:838

Datasets

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Paper Phenotype Condition Medium Collection Tested mutants Data Details
Sousa M~Sousa MJ, 2013 cell death (frequency of dead cells) acetic acid [400 mM], pH [3.0], time [100-350 min] YPD hap a ~5,080 Discrete

Curation history

Data

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