Cohen N~Schuldiner M, 2017

Pubmed ID 28794014
Title Iron affects Ire1 clustering propensity and the amplitude of endoplasmic reticulum stress signaling.
Authors Nir Cohen, Michal Breker, Anush Bakunts, Kristina Pesek, Ainara Chas, Josepmaria Argemí, Andrea Orsi, Lihi Gal, Silvia Chuartzman, Yoav Wigelman, Felix Jonas, Peter Walter, Robert Ernst, Tomás Aragón, Eelco van Anken, Maya Schuldiner
Abstract 3+) affects UPR activation in both yeast and human cells. We suggest that Ire1 clustering propensity depends on membrane composition, which is governed by heme-dependent biosynthesis of sterols. Our findings highlight the diverse cellular functions that feed into the UPR and emphasize the cross-talk between organelles required to concertedly maintain homeostasis.
Citation J. Cell. Sci. 2017; 130:3222-3233

Datasets

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Paper Phenotype Condition Reference Collection Tested mutants Data Details
Cohen N~Schuldiner M, 2017 protein aggregates (Ire1) 1,4-dithiothreitol [2 mM] hom ~4,757 Discrete

Curation history

Tested strains

Sept. 20, 2017 To request.
Feb. 22, 2018 Request sent.
Feb. 26, 2018 Ready to load.
March 5, 2018 Loaded.

Data

Sept. 20, 2017 Waiting for tested.
Feb. 26, 2018 Ready to load.
March 5, 2018 Loaded.