||Application of the comprehensive set of heterozygous yeast deletion mutants to elucidate the molecular basis of cellular chromium toxicity.
||Sara Holland, Emma Lodwig, Theodora Sideri, Tom Reader, Ian Clarke, Konstantinos Gkargkas, David C Hoyle, Daniela Delneri, Stephen G Oliver, Simon V Avery
||The serious biological consequences of metal toxicity are well documented, but the key modes of action of most metals are unknown. To help unravel molecular mechanisms underlying the action of chromium, a metal of major toxicological importance, we grew over 6,000 heterozygous yeast mutants in competition in the presence of chromium. Microarray-based screens of these heterozygotes are truly genome-wide as they include both essential and non-essential genes.
||Genome Biol. 2007; 8:R268
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