Holland S~Avery SV, 2007

Pubmed ID 18088421
Title Application of the comprehensive set of heterozygous yeast deletion mutants to elucidate the molecular basis of cellular chromium toxicity.
Authors Sara Holland, Emma Lodwig, Theodora Sideri, Tom Reader, Ian Clarke, Konstantinos Gkargkas, David C Hoyle, Daniela Delneri, Stephen G Oliver, Simon V Avery
Abstract The serious biological consequences of metal toxicity are well documented, but the key modes of action of most metals are unknown. To help unravel molecular mechanisms underlying the action of chromium, a metal of major toxicological importance, we grew over 6,000 heterozygous yeast mutants in competition in the presence of chromium. Microarray-based screens of these heterozygotes are truly genome-wide as they include both essential and non-essential genes.
Citation Genome Biol. 2007; 8:R268


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Paper Phenotype Condition Medium Collection Tested mutants Data Details
Holland S~Avery SV, 2007 growth (pooled culture) chromium trioxide [0.1 mM] het 5,237 Quantitative

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