Chen X~Petranovic D, 2020

Pubmed ID 32054832
Title FMN reduces Amyloid-β toxicity in yeast by regulating redox status and cellular metabolism.
Authors Xin Chen, Boyang Ji, Xinxin Hao, Xiaowei Li, Frederik Eisele, Thomas Nyström, Dina Petranovic
Abstract +) ratios and increasing resistance to oxidative stress. Additionally, FMN supplementation modifies Htt103QP toxicity and α-synuclein toxicity in the humanized yeast. Our findings offer insights for reducing cytotoxicity of Aβ42, and potentially other misfolded proteins, via FMN-dependent cellular pathways.
Citation Nat Commun 2020; 11:867
Data abstract Deletion collection was tested for amyloid-beta peptide toxicity (AB42).

Datasets

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Paper Phenotype Condition Medium Collection Tested mutants Data Details
Chen X~Petranovic D, 2020 growth (colony size) expression of amyloid-beta 42 hap a (post-SGA) ~4,300 Quantitative only for hits

Curation history

Data

April 3, 2020 To request.
May 1, 2020 Request sent.

Tested strains

April 3, 2020 To request.
May 1, 2020 Request sent.