||FMN reduces Amyloid-β toxicity in yeast by regulating redox status and cellular metabolism.
||Xin Chen, Boyang Ji, Xinxin Hao, Xiaowei Li, Frederik Eisele, Thomas Nyström, Dina Petranovic
||+) ratios and increasing resistance to oxidative stress. Additionally, FMN supplementation modifies Htt103QP toxicity and α-synuclein toxicity in the humanized yeast. Our findings offer insights for reducing cytotoxicity of Aβ42, and potentially other misfolded proteins, via FMN-dependent cellular pathways.
||Nat Commun 2020; 11:867
||Deletion collection was tested for amyloid-beta peptide toxicity (AB42).
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