McKinney JS~Lewis LK, 2013

Pubmed ID 23586741
Title A multistep genomic screen identifies new genes required for repair of DNA double-strand breaks in Saccharomyces cerevisiae.
Authors Jennifer Summers McKinney, Sunaina Sethi, Jennifer DeMars Tripp, Thuy N Nguyen, Brian A Sanderson, James W Westmoreland, Michael A Resnick, L Kevin Lewis
Abstract Efficient mechanisms for rejoining of DNA double-strand breaks (DSBs) are vital because misrepair of such lesions leads to mutation, aneuploidy and loss of cell viability. DSB repair is mediated by proteins acting in two major pathways, called homologous recombination and nonhomologous end-joining. Repair efficiency is also modulated by other processes such as sister chromatid cohesion, nucleosome remodeling and DNA damage checkpoints. The total number of genes influencing DSB repair efficiency is unknown.
Citation BMC Genomics 2013; 14:251


Curation history


Aug. 7, 2020 Not relevant.

Tested strains

Aug. 7, 2020 Not relevant.