|Title||Genomic profiling of fungal cell wall-interfering compounds: identification of a common gene signature.|
|Authors||Raúl García, Javier Botet, José Manuel Rodríguez-Peña, Clara Bermejo, Juan Carlos Ribas, José Luis Revuelta, César Nombela, Javier Arroyo|
|Abstract||The fungal cell wall forms a compact network whose integrity is essential for cell morphology and viability. Thus, fungal cells have evolved mechanisms to elicit adequate adaptive responses when cell wall integrity (CWI) is compromised. Functional genomic approaches provide a unique opportunity to globally characterize these adaptive mechanisms. To provide a global perspective on these CWI regulatory mechanisms, we developed chemical-genomic profiling of haploid mutant budding yeast cells to systematically identify in parallel those genes required to cope with stresses interfering the cell wall by different modes of action: β-1,3 glucanase and chitinase activities (zymolyase), inhibition of β-1,3 glucan synthase (caspofungin) and binding to chitin (Congo red).|
|Citation||BMC Genomics 2015; 16:683|
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