Jarosz DF~Lindquist S, 2014

Pubmed ID 25171409
Title Cross-kingdom chemical communication drives a heritable, mutually beneficial prion-based transformation of metabolism.
Authors Daniel F Jarosz, Jessica C S Brown, Gordon A Walker, Manoshi S Datta, W Lloyd Ung, Alex K Lancaster, Assaf Rotem, Amelia Chang, Gregory A Newby, David A Weitz, Linda F Bisson, Susan Lindquist
Abstract In experimental science, organisms are usually studied in isolation, but in the wild, they compete and cooperate in complex communities. We report a system for cross-kingdom communication by which bacteria heritably transform yeast metabolism. An ancient biological circuit blocks yeast from using other carbon sources in the presence of glucose. [GAR(+)], a protein-based epigenetic element, allows yeast to circumvent this "glucose repression" and use multiple carbon sources in the presence of glucose. Some bacteria secrete a chemical factor that induces [GAR(+)]. [GAR(+)] is advantageous to bacteria because yeast cells make less ethanol and is advantageous to yeast because their growth and long-term viability is improved in complex carbon sources. This cross-kingdom communication is broadly conserved, providing a compelling argument for its adaptive value. By heritably transforming growth and survival strategies in response to the selective pressures of life in a biological community, [GAR(+)] presents a unique example of Lamarckian inheritance.
Citation Cell 2014; 158:1083-1093

Datasets

Download the list of datasets
Paper Phenotype Condition Medium Collection Tested mutants Data Details
Jarosz DF~Lindquist S, 2014 growth (colony size) exposure to S. hominis [GAR+] prion GGM hap ? ~4,848 Discrete

Curation history

Data

June 25, 2020 Waiting for tested.
July 10, 2020 Ready to load.
July 10, 2020 Not available.
July 16, 2020 Loaded.

Tested strains

June 25, 2020 Request sent.
June 25, 2020 To request.
July 10, 2020 Not available.