|Title||Mitochondria-anchored receptor Atg32 mediates degradation of mitochondria via selective autophagy.|
|Authors||Koji Okamoto, Noriko Kondo-Okamoto, Yoshinori Ohsumi|
|Abstract||Mitochondria are essential organelles that produce most of the energy for a cell, but concomitantly accumulate oxidative damage. Degradation of damaged mitochondria is critical for cell homeostasis, and this process is thought to be mediated by mitophagy, an autophagy-related pathway specific for mitochondria. However, whether mitochondria are selectively degraded, and how the autophagic machinery is targeted to mitochondria, remain largely unknown. Here we demonstrate that, in post-log phase cells under respiratory conditions, a substantial fraction of mitochondria are exclusively sequestered as cargoes and transported to the vacuole, a lytic compartment in yeast, in an autophagy-dependent manner. Interestingly, we found Atg32, a mitochondria-anchored protein essential for mitophagy that is induced during respiratory growth. In addition, our data suggest that Atg32 interacts with Atg8 and Atg11, autophagy-related proteins critical for recognition of cargo receptors. We propose that Atg32 acts as a mitophagy-specific receptor and regulates selective degradation of mitochondria.|
|Citation||Dev. Cell 2009; 17:87-97|
YeastPhenome.org is running in beta version. The data are available for download, but, as of today, we cannot guarantee lack of errors or code bugs introduced during processing. This warning will be removed after all cross-checks and validations have been completed. In the meantime, please, be careful when using the data.