Emadi A~Vuica-Ross M, 2010

Pubmed ID 20520766
Title A chemical genetic screen for modulators of asymmetrical 2,2'-dimeric naphthoquinones cytotoxicity in yeast.
Authors Ashkan Emadi, Ashley E Ross, Kathleen M Cowan, Yolanda M Fortenberry, Milena Vuica-Ross
Abstract Dimeric naphthoquinones (BiQ) were originally synthesized as a new class of HIV integrase inhibitors but have shown integrase-independent cytotoxicity in acute lymphoblastic leukemia cell lines suggesting their use as potential anti-neoplastic agents. The mechanism of this cytotoxicity is unknown. In order to gain insight into the mode of action of binaphthoquinones we performed a systematic high-throughput screen in a yeast isogenic deletion mutant array for enhanced or suppressed growth in the presence of binaphthoquinones.
Citation PLoS One 2010; 5:e10846

Datasets

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Paper Phenotype Condition Medium Collection Tested mutants Data Details
Emadi A~Vuica-Ross M, 2010 growth (culture turbidity) BiQ3 [7 uM] SC - Ura hap a ~5,000 None
Emadi A~Vuica-Ross M, 2010 growth (culture turbidity) BiQ7 [0.9 uM] SC - Ura hap a ~5,000 None
Emadi A~Vuica-Ross M, 2010 growth (culture turbidity) 6-azauracil SC - Ura hap a ~5,000 None
Emadi A~Vuica-Ross M, 2010 growth (colony size) BiQ3 [7 uM] hap a ~5,000 Discrete
Emadi A~Vuica-Ross M, 2010 growth (colony size) BiQ7 [3 uM] hap a ~5,000 Discrete
Emadi A~Vuica-Ross M, 2010 growth (colony size) BiQ11 [7 uM] hap a ~5,000 Discrete

Curation history

Tested strains

Oct. 28, 2020 Request sent.
Oct. 28, 2020 To request.

Data

Oct. 28, 2020 Request sent.
Oct. 28, 2020 To request.