||A genome-wide deletion mutant screen identifies pathways affected by nickel sulfate in Saccharomyces cerevisiae.
||Adriana Arita, Xue Zhou, Thomas P Ellen, Xin Liu, Jingxiang Bai, John P Rooney, Adrienne Kurtz, Catherine B Klein, Wei Dai, Thomas J Begley, Max Costa
||The understanding of the biological function, regulation, and cellular interactions of the yeast genome and proteome, along with the high conservation in gene function found between yeast genes and their human homologues, has allowed for Saccharomyces cerevisiae to be used as a model organism to deduce biological processes in human cells. Here, we have completed a systematic screen of the entire set of 4,733 haploid S. cerevisiae gene deletion strains (the entire set of nonessential genes for this organism) to identify gene products that modulate cellular toxicity to nickel sulfate (NiSO(4)).
||BMC Genomics 2009; 10:524
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