Jorgensen P~Tyers M, 2002

Pubmed ID 12089449
Title Systematic identification of pathways that couple cell growth and division in yeast.
Authors Paul Jorgensen, Joy L Nishikawa, Bobby-Joe Breitkreutz, Mike Tyers
Abstract Size homeostasis in budding yeast requires that cells grow to a critical size before commitment to division in the late prereplicative growth phase of the cell cycle, an event termed Start. We determined cell size distributions for the complete set of approximately 6000 Saccharomyces cerevisiae gene deletion strains and identified approximately 500 abnormally small (whi) or large (lge) mutants. Genetic analysis revealed a complex network of newly found factors that govern critical cell size at Start, the most potent of which were Sfp1, Sch9, Cdh1, Prs3, and Whi5. Ribosome biogenesis is intimately linked to cell size through Sfp1, a transcription factor that controls the expression of at least 60 genes implicated in ribosome assembly. Cell growth and division appear to be coupled by multiple conserved mechanisms.
Citation Science 2002; 297:395-400

Datasets

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Papers Phenotype Conditions Collection Tested mutants Data Details
Jorgensen P~Tyers M, 2002 cell size YPD [standard] hap ? ~4,812 Quantitative only for hits
Jorgensen P~Tyers M, 2002 cell size YPD [standard] het ~1,142 Quantitative only for hits

Curation history

Data

Feb. 12, 2014 Data requested.
Feb. 15, 2016 Data abandoned.
Feb. 15, 2016 Data loaded.

Tested strains

April 11, 2017 Tested strains abandoned.