Postma L~Ralser M, 2009

Pubmed ID 20157578
Title Surviving in the cold: yeast mutants with extended hibernating lifespan are oxidant sensitive.
Authors Lucie Postma, Hans Lehrach, Markus Ralser
Abstract Metabolic activity generates oxidizing molecules throughout life, but it is still debated if the resulting damage of macromolecules is a causality, or consequence, of the aging process. This problem demands for studying growth- and longevity phenotypes separately. Here, we assayed a complete collection of haploid Saccharomyces cerevisiae knock-out strains for their capacity to endure long periods at low metabolic rates. Deletion of 93 genes, predominantly factors of primary metabolism, allowed yeast to survive for more than 58 months in the cold. The majority of these deletion strains were not resistant against oxidants or reductants, but many were hypersensitive. Hence, survival at low metabolic rates has limiting genetic components, and correlates with stress resistance inversely. Indeed, maintaining the energy consuming anti-oxidative machinery seems to be disadvantageous under coldroom conditions.
Citation Aging (Albany NY) 2009; 1:957-60


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Paper Phenotype Condition Medium Collection Tested mutants Data Details
Postma L~Ralser M, 2009 growth (spot assay) temperature [4ÂșC], time [12-58 months] YPD hap a 4,906 Discrete

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