Jo WJ~Vulpe CD, 2009

Pubmed ID 19321002
Title Novel insights into iron metabolism by integrating deletome and transcriptome analysis in an iron deficiency model of the yeast Saccharomyces cerevisiae.
Authors William J Jo, Jeung Hyoun Kim, Eric Oh, Daniel Jaramillo, Patricia Holman, Alex V Loguinov, Adam P Arkin, Corey Nislow, Guri Giaever, Chris D Vulpe
Abstract Iron-deficiency anemia is the most prevalent form of anemia world-wide. The yeast Saccharomyces cerevisiae has been used as a model of cellular iron deficiency, in part because many of its cellular pathways are conserved. To better understand how cells respond to changes in iron availability, we profiled the yeast genome with a parallel analysis of homozygous deletion mutants to identify essential components and cellular processes required for optimal growth under iron-limited conditions. To complement this analysis, we compared those genes identified as important for fitness to those that were differentially-expressed in the same conditions. The resulting analysis provides a global perspective on the cellular processes involved in iron metabolism.
Citation BMC Genomics 2009; 10:130


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Paper Phenotype Condition Medium Collection Tested mutants Data Details
Jo WJ~Vulpe CD, 2009 growth (pooled culture) iron limitation YPD hom ~4,757 Quantitative only for hits

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